Jessica Kohlschmidt

Dr. Jessica K. Kohlschmidt grew up in Houston, Texas, with five siblings. She was encouraged to pursue a college education so she could always support herself if she needed to. A first-generation college student, she had a passion for math from a young age and grew up with an interest in teaching. She would teach dolls or children—whichever was available. Thus, it was an easy choice to study math and teaching in college, although that has looked different throughout her life.

Dr. Kohlschmidt pursued a degree in mathematics and, through a series of curious events—including a required statistics class—she ended up minoring in statistics. Statistics was a real-world application of math that made sense and inspired her. Therefore, when Sam Houston State University created a new master’s in statistics program, she joined the program. Later, she attended The Ohio State University and earned a Ph.D. Dr. Kohlschmidt dreamed of sharing her inspiration with others and envisioned that would happen through teaching in a college classroom.

Dr. Kohlschmidt has taught full and part-time at colleges since 1999. She enjoys helping students learn and grow their critical thinking skills. She knows statistics is a topic that is stressful for many people and hopes to help them on their journey with this material.

Dr. Kohlschmidt was the PhD biostatistician at the Clara D. Bloomfield Center for Leukemia Outcomes Research at The Ohio State University Comprehensive Cancer Center for 12 years. Her research group looked retrospectively at patient data to determine what gene mutations and expression (or combinations) predict which patients will have improved survival. This helped direct prospective clinical trials. In that role, Dr. Kohlschmidt was a consulting statistician and had the opportunity to apply statistics to real-world problems and teach collaborators about statistics and how to interpret results in a meaningful and appropriate way.

A longtime officer of the Caucus for Women in Statistics (CWS)—serving for 10 years as secretary and, in 2018, as the first executive director— Dr. Kohlschmidt currently oversees CWS operations. She has been involved with many of the updates that have occurred in the past few years and is enthusiastic about the new directions CWS has undertaken, including efforts to increase international visibility and outreach to young people. Dr. Kohlschmidt has a passion for helping young people, especially girls, learn about statistics and explore it as a career option. This is something she has been able to do more of through CWS and the Florence Nightingale Day event that has occurred the last five years and is sponsored by the CWS and American Statistical Association (ASA).

Dr. Kohlschmidt is actively involved with the ASA and serves as Vice Chair for District 3 for the Chapter of Councils, past president for the Columbus Chapter, and co-chair for the History in Statistics Interest Group. She feels honored when her work and effort are appreciated and when a student or collaborator expresses gratitude for the help and understanding of statistics she has provided.

• PhD in Statistics, The Ohio State University
• MS in Statistics, The Ohio State University
• MS in Statistics, Sam Houston State University
• BS in Mathematics with Honors, Sam Houston State University

Educational Materials:

Kohlschmidt, JK. (2004).  Navidi’s PowerPoint Slides for Statistics for Engineers and Scientists (1^st ed.).

Kohlschmidt, JK. and Rumsey, D. (2005). Excel How-to Guide. Thomson Custom Publishing.

Kohlschmidt, JK. and Rumsey, D. (2005). Excel StatTools How-to Guide. Thomson Custom Publishing.

Kohlschmidt, JK. and Rumsey, D. (2005). Minitab How-to Guide. Thomson Custom Publishing. Bundled with Business Statistics Textbook.

Kohlschmidt, JK. and Miller, J. (2005). TI-84 How-to Guide. Thomson Custom Publishing.

Kohlschmidt, JK. and Miller, J. (2005). TI-89 How-to Guide. Thomson Custom Publishing.

Kohlschmidt, JK. (2006).  Navidi’s PowerPoint Slides for Statistics for Engineers and Scientists (2^nd ed.).

Referred Journals:

Becker H, Maharry K, Radmacher MD, Mrózek K, Metzeler KH, Whitman SP, Schwind S, Kohlschmidt J, Wu Y-Z, Powell BL, Carter TH, Kolitz JE, Wetzler M, Carroll AJ, Baer MR, Moore JO, Caligiuri MA, Larson RA, Marcucci G*, Bloomfield CD*. Clinical outcome and gene- and microRNA-expression profiling according to the Wilms tumor 1 (WT1) single nucleotide polymorphism rs16754 in adult de novo cytogenetically normal acute myeloid leukemia: A Cancer and Leukemia Group B study.  Haematologica. 2011 Oct 1;96(10):1488-95. Epub 2011 Jun 9. PMID: 21659357. PMCID: 3186310. 

Schwind S, Marcucci G, Kohlschmidt J, Radmacher MD, Mrózek K, Maharry K, Becker H, Metzeler KH, Whitman SP, Wu YZ, Powell BL, Baer MR, Kolitz JE, Carroll AJ, Larson RA, Caligiuri MA*, Bloomfield CD*. Low expression of MN1 associates with better treatment response in older patients with de novo cytogenetically normal acute myeloid leukemia. Blood. 2011 Oct 13;118(15):4188-98. Epub 2011 Aug 9. PMID: 21828125. PMCID: 3291490.

Metzeler KH, Becker H, Maharry K, Radmacher MD, Kohlschmidt J, Mrozek, Nicolet D, Whitman SP, Wu YZ, Schwind S, Powell BL, Carter TH, Wetzler M, Moore JO, Kolitz JE, Baer MR, Carroll AJ, Larson RA, Caligiuri MA, Marcucci G*, Bloomfield CD*. ASXL1 mutations identify a high-risk subgroup of older patients with primary cytogenetically normal AML within the ELN Favorable genetic category. Blood. 2011 Dec 22;118(26):6920-9. Epub 2011 Oct 26. PMID: 22031865. PMCID: 3245212. 

Marcucci G, Metzeler KH, Schwind S, Becker H, Maharry K, Mrózek K, Radmacher MD, Kohlschmidt J, Nicolet D, Whitman SP, Wu Y-Z, Powell BL, Carter TH, Kolitz JE, Wetzler M, Carroll AJ, Baer MR, Moore JO, Caligiuri MA, Larson RA, Bloomfield CD. Age-related prognostic impact of different types of DNMT3A mutations in adults with primary cytogenetically normal acute myeloid leukemia. J Clin Oncol. 2012 Mar 1;30(7):742-50. Epub 2012 Jan 30. PMID: 22291079. PMCID: 3295550.

Whitman SP, Caligiuri MA, Maharry K, Radmacher MD, Kohlschmidt, J, Becker H, Mrózek K, Wu Y-Z, Schwind S, Metzeler KH, Mendler JH, Wen J, Baer MR, Powell BL, Carter TH, Kolitz JE, Wetzler M, Carroll AJ, Larson RA, Marcucci G*, Bloomfield CD*. The MLL partial tandem duplication in adults aged 60 years and older with de novo cytogenetically normal acute myeloid leukemia. Leukemia. 2012 Jul;26(7):1713-7. Epub 2012 Feb 7. PMID: 22382894. PMCID: 3565839.

Kohlschmidt, JK, Stasny, EA, Wolfe, DA.. Ranked set sampling for a population proportion: Allocation of sample units to each judgment order statistic.  Pakistan Journal of Statistics and Operations Research (Statistics in the Twenty-First Century: Special Volume in Honour of Distinguished Professor Dr. Mir Masoom Ali On the Occasion of his 75th Birthday Anniversary, 8(2012), 511-530.  (Also, in the 2005 Proceedings of the American Statistical Association, Section on Nonparametric Statistics [CD-ROM], Alexandria, VA: American Statistical Association: 3235-3242)

Mendler JH, Maharry K, Radmacher MD, Mrózek K, Becker H, Metzeler K, Schwind S, Whitman SP, Khalife J, Kohlschmidt J, Nicolet D, Powell BL, Carter TH, Wetzler M, Moore JO, Kolitz JE, Baer MR, Carroll AJ, Larson RA, Caligiuri MA, Marcucci G*, Bloomfield CD*. RUNX1 Mutations Are Associated With Poor Outcome in Younger and Older Patients With Cytogenetically Normal Acute Myeloid Leukemia and With Distinct Gene and MicroRNA Expression Signatures. J Clin Oncol. 2012 Sep 1;30(25):3109-18. Epub 2012 Jul 2. PMID: 22753902. PMCID: 3732007.

Mrózek K, Marcucci G, Nicolet D, Maharry KS, Becker H, Whitman SP, Metzeler KH, Schwind S, Wu Y-Z, Kohlschmidt J, Pettenati MJ, Heerema NA, Block AW, Patil SR, Baer MR, Kolitz JE, Moore JO, Carroll AJ, Stone RM, Larson RA, Bloomfield CD. Prognostic Significance of the European LeukemiaNet Standardized System for Reporting Cytogenetic and Molecular Alterations in Adults With Acute Myeloid Leukemia. J Clin Oncol. 2012 Dec 20;30(36):4515-4523. Epub 2012 Sep 17. PMID: 22987078. PMCID: 3518729.

Schwind S, Edwards CG, Nicolet D, Mrózek K, Maharry K, Wu Y-Z, Paschka P, Eisfeld A-K, Hoellerbauer P, Becker H, Metzeler KH, Curfman J, Kohlschmidt J, Prior TW, Kolitz JE, Blum W, Pettenati MJ, Dal Cin P, Carroll AJ, Caligiuri MA, Larson RA, Volinia S, Marcucci G*, Bloomfield CD*. inv(16)/t(16;16) acute myeloid leukemia with non-type A CBFB-MYH11 fusions associate with distinct clinical and genetic features and lack KIT mutations. Blood. 2013 Jan 10;121(2):385-91. Epub 2012 Nov 16. PMID: 23160462. PMCID: 3544117.

Walker A, Mrózek K, Kohlschmidt J, Rao KW, Pettenati MJ, Sterling LJ, Marcucci G, Carroll AJ, Bloomfield CD. New Recurrent Balanced Translocations in Acute Myeloid Leukemia and Myelodysplastic Syndromes: Cancer and Leukemia Group B (CALGB) 8461. Genes, Chromosomes and Cancer. 2013 Apr;52(4):385-401. Epub 2012 Dec 10. PMID: 23225546. PMCID: 3874732. 

Marcucci G, Maharry K, Metzeler KH, Volinia S, Wu Y-Z, Mrózek K, Nicolet D, Kohlschmidt J, Whitman SP, Mendler JH, Schwind S, Becker H, Eisfeld A-K, Carroll AJ, Powell BL, Kolitz JE, Garzon R, Caligiuri MA, Stone RM, Bloomfield CD. The Clinical Role of microRNAs in Cytogenetically Normal Acute Myeloid Leukemia: miR-155 Upregulation Independently Identifies High-Risk Patients. J Clin Oncol. 2013 Jun 10;31(17):2086-93. Epub 2013 May 6. PMID: 23650424. PMCID: 3731981.

Mendler JH, Maharry K,  Becker H, Eisfeld A-K, Senter L, Mrózek K, Kohlschmidt J, Metzeler KH, Schwind S, Whitman SP, Khalife J, Caligiuri MA, Klisovic RB, Moore JO, Carter TH, Marcucci G*, Bloomfield CD*. In rare acute myeloid leukemia patients harboring both RUNX1 and NPM1 mutations, RUNX1 mutations are unusual in structure and present in the germline. Letter to the Editor. Haematologica. 2013 Aug;98(8):e92-4. Epub 2013 Jun 10. PMID: 23753029. PMCID: 3729891.​​​​​​

Metzeler KH, Maharry K, Kohlschmidt J, Volinia S, Mrózek K, Becker H, Nicolet D, Whitman SP, Mendler JH, Schwind S, Eisfeld A-K, Wu Y-Z, Powell BL, Carter TH, Wetzler M, Kolitz JE, Baer MR, Carroll AJ, Stone RM, Caligiuri MA, Marcucci G*, Bloomfield CD*. A stem cell-like gene expression signature associates with inferior outcomes and a distinct microRNA expression profile in adults with primary cytogenetically normal acute myeloid leukemia. Leukemia. 2013 Oct;27(10):2023-31. Epub 2013 Jun 14. PMID: 23765227. PMCID: 3890747. 

Wetzler M, Mrózek K, Kohlschmidt J, Dombret H, Döhner H, Pilorge S, Krug U, Carroll AJ, Larson RA, Marcucci G, Hiddemann W, Büchner T, Bloomfield CD. Intensive induction is effective in select octogenarian acute myeloid leukemia patients: prognostic significance of karyotype and selected molecular markers used in the European Leukemia-Net classification. Haematologica. 2014 Feb;99(2):308-13. Epub 2013 Oct 4. PMID: 24097631. PMCID: 3912961.

Whitman S, Kohlschmidt J, Maharry K, Volinia S, Mrózek K, Nicolet D, Schwind S, Becker H, Metzeler KH, Mendler JH, Eisfeld A-K, Carroll AJ, Powell BL, Carter TH, Baer MR, Kolitz JE, Park I-K, Stone RM, Caligiuri MA*, Marcucci G*, Bloomfield CD*. GAS6 expression identifies high-risk adult AML patients: potential implications for therapy. Leukemia. 2014 Jun;28(6):1252-8. Epub 2013 Dec 11. PMID: 24326683. PMCID: 4047202.

Marcucci G, Yan P, Maharry K, Frankhouser D, Nicolet D, Metzeler KH, Kohlschmidt J, Mrózek K, Wu Y-Z, Bucci D, Whitman SP, Eisfeld A-K, Mendler JH, Schwind S, Becker H, Bär C, Carroll AJ, Baer MR, Wetzler M, Carter TH, Powell BL, Kolitz JE, Byrd JC, Plass C, Garzon R, Caligiuri MA, Stone RM, Volinia S, Bundschuh R*, Bloomfield CD*. Epigenetics Meets Genetics in Acute Myeloid Leukemia: Clinical Impact of a Novel Seven-Gene Score. J Clin Oncol. 2014 Feb 20;32(6):548-56. Epub 2013 Dec 30. PMID:  24378410. PMCID: 3918538.

Alachkar H, Santhanam R, Maharry K, Metzeler KH, Huang X, Kohlschmidt J, Mendler JH, Benito JM, Hickey C, Neviani P, Dorrance AM, Anghelina M, Khalife J, Samadzadeh ST, Volinia S, Whitman SP, Paschka P, Hoellerbauer P, Wu Y-Z, Han L, Bolon BN, Blum W, Mrózek K, Carroll AJ, Perrotti D, Andreeff M, Caligiuri MA, Konopleva M, Garzon R, Bloomfield CD*, Marcucci G*. SPARC promotes leukemic cell growth and predicts acute myeloid leukemia outcome. J Clin Invest. 2014 Apr 1;124(4):1512-24. Epub 2014 Mar 3. PMID: 24590286. PMCID: 3973087.

Becker H, Maharry K, Mrózek K, Volinia S, Eisfeld A-K, Radmacher MD, Kohlschmidt J, Metzeler KH, Schwind S, Whitman SP, Mendler JH, Wu Y-Z, Nicolet D, Paschka P, Powell BL, Carter TH, Wetzler M, Kolitz JE, Carroll AJ, Baer MR, Caligiuri MA, Stone RM, Marcucci G*, Bloomfield CD*. Prognostic gene mutations and distinct gene- and microRNA-expression in acute myeloid leukemia with a sole trisomy 8. Letter to the editor. Leukemia. 2014 Aug 6;28(8):1754-8. Epub 2014 Mar 21. PMID: 24651097. PMCID: 4151613.

Niederwieser C, Kohlschmidt J, Volinia S, Whitman SP, Metzeler KH, Eisfeld A-K, Maharry K, Yan P, Frankhouser D, Becker H, Schwind S, Carroll AJ, Nicolet D, Mendler JH, Curfman JP, Wu Y-Z, Baer MR, Powell BL, Kolitz JE, Moore JO, Carter TH, Bundschuh R, Larson RA, Stone RM, Mrózek K*, Marcucci G*, Bloomfield CD*. Prognostic and biologic significance of DNMT3B expression in older patients with cytogenetically normal primary acute myeloid leukemia. Leukemia. 2015 Mar;29(3):567-75. Epub 2014 Sep 10. PMID: 25204569. PMCID: 4351165.

Roberts KG, Li Y, Payne-Turner D, Harvey RC, Yang Y-L,  Pei D, McCastlain K, Ding L, Lu C, Song G, Ma J, Becksfort J, Rusch M, Chen S-C, Easton J, Cheng J, Boggs K, Santiago-Morales N, Iacobucci I, Fulton RS, Wen J, Valentine M, Cheng C, Paugh SW, Devidas M, Chen I-M, Reshmi S, Smith A, Hedlund E, Gupta P, Nagahawatte P, Wu G, Chen X, Yergeau D, Vadodaria B, Mulder H, Winick NJ, Larsen EC, Carroll WL, Heerema NA, Carroll AJ, Grayson G, Tasian SK, Moore AS, Keller F, Frei-Jones M, Whitlock JA, Raetz EA, White DL, Hughes TP,  Guidry Auvil JM, Smith MA, Marcucci G, Bloomfield CD, Mrózek K, Kohlschmidt J, Stock W, Kornblau SM, Konopleva M, Paietta E, Pui C-H, Jeha S, Relling MV, Evans WE, Gerhard DS, Gastier-Foster JM, Mardis E, Wilson RK, Loh ML, Downing JR, Hunger SP, Willman CL, Zhang J, Mullighan CG. Targetable Kinase-Activating Lesions in Ph-like Acute Lymphoblastic Leukemia. N Engl J Med. 2014  Sep 11;371(11):1005-1015. PMID: 25207766. PMCID: 4191900.

Perez-Andreu V, Roberts KG, Xu H, Smith C, Zhang H, Yang W, Harvey RC, Payne-Turner D, Devidas M, Chen I-M, Carroll WL, Heerema NA, Carroll AJ, Raetz EA, Gastier-Foster JM, Marcucci G, Bloomfield CD, Mrózek K, Kohlschmidt J, Stock W, Kornblau SM, Konopleva M, Paietta E, Pui C-H, Jeha S, Relling MV, Evans WE, Gerhard DS, Loh ML, Willman CL, Hunger SP, Mullighan CG, Yang JJ. A genome-wide association study of susceptibility to acute lymphoblastic leukemia in adolescents and young adults. Blood. 2015 Jan 22;125(4):680-6. Epub 2014 Dec 2. PMID: 25468567. PMCID: 4304112..

Garzon R, Volinia S, Papaioannou D, Nicolet D, Kohlschmidt J, Yan P, Mrózek K, Bucci D, Carroll AJ, Baer MR, Wetzler M, Carter TH, Powell BL, Kolitz JE, Moore JO, Eisfeld A-K, Blachly JS, Blum W, Caligiuri MA, Stone RM, Marcucci G, Croce CM, Byrd JC, Bloomfield CD. Expression and prognostic impact of lncRNAs in acute myeloid leukemia. Proc Natl Acad Sci U S A. 2014 Dec 30;111(52):18679-18684. Epub 2014 Dec 15. PMID: 25512507. PMCID:4284555.

​​​​​​​Sood R, Hansen NF, Donovan FX, Carrington B, Bucci D, Maskeri B, Young A, Trivedi NS, Kohlschmidt J, Stone RM, Caligiuri MA, Chandrasekharappa SC, Marcucci G, Mullikin JC, Bloomfield CD, Liu P. Somatic mutational landscape of AML with inv(16) and t(8;21) identifies patterns of clonal evolution in relapse leukemia. Leukemia. 2016 Feb;30(2):201-4. Epub 2015 Jun15. PMID: 26139325. PMCID: 4679720.

​​​​​​​Bhatnagar B, Blachly JS, Kohlschmidt J, Eisfeld A-K, Volinia S, Nicolet D, Carroll AJ, Block AM, Kolitz JE, Stone RM, Mrózek K, Byrd JC, Bloomfield CD. Clinical features, and gene- and microRNA-expression patterns in adult acute leukemia patients with t(11;19)(q23;p13.1) and t(11;19)(q23;p13.3). Leukemia. 2016 Jul;30(7):1586-9. Epub 2015 Dec 16. PMID: 26669971. PMCID: 5004206.

​​​​​​​Niederwieser C, Nicolet D, Carroll AJ, Kolitz JE, Powell BL, Kohlschmidt J, Stone RM, Byrd JC, Mrózek K, Bloomfield CD. Chromosome abnormalities at onset of complete remission are associated with worse outcome in patients with acute myeloid leukemia and an abnormal karyotype at diagnosis: CALGB 8461 (Alliance). Haematologica. 2016 Dec;101(12):1516-1523. Epub 2016 Jul 28. PMID: 27470602. PMCID: 5479622.

Bhatnagar B, Eisfeld A-K, Nicolet D, Mrózek K, Blachly JS, Orwick S, Lucas DM, Kohlschmidt J, Blum W, Kolitz JE, RM, Bloomfield CD*, Byrd JC*. Persistence of isolated DNMT3A R882 mutations during remission does not adversely affect outcomes of patients with acute myeloid leukemia. Br J Haematol. 2016 Oct;175(2):226-236. Epub 2016 Aug 1. PMID: 27476855. PMCID: 5063708.

Eisfeld A-K, Kohlschmidt J, Mrózek K, Blachly JS, Nicolet D, Kroll K, Orwick S, Carroll AJ, Stone RM, de la Chapelle A, Byrd JC,  Bloomfield CD. Adult acute myeloid leukemia with trisomy 11 as the sole abnormality is characterized by the presence of five distinct gene mutations: MLL-PTD, DNMT3A, U2AF1, FLT3-ITD and IDH2. Leukemia. 2016 Nov;30(11):2254-2258. Epub 2016 Aug 12. PMID: 27435003. PMCID: 5244485.

Blum W, Sanford B, Klisovic R, DeAngelo DJ, Uy G, Powell BL, Stock W, Baer MR, Kolitz JE, Wetzler M, Hoke E, Mrózek K, Kohlschmidt J, Bloomfield CD, Geyer S, Marcucci G, Stone RM, Larson RA. Maintenance Therapy with Decitabine in Younger Adults with Acute Myeloid Leukemia in First Remission: a Phase II Cancer and Leukemia Group B Study (CALGB 10503). Leukemia. 2017 Jan;31(1):34-39. Epub 2016 Oct 7. PMID: 27624549. PMCID: 5214595.

Zhang J, McCastlain K, Yoshihara H,  Xu B, Chang Y, Churchman ML, Wu G, Li Y, Wei L, Iacobucci I, Liu Y, Qu C, Shao Y, Wen J, Edmonson M, Payne-Turner D, Kaufmann KB, Takayanagi S-I, Wienholds E, Waanders E, Ntziachristos P, Bokogianni S, Wang J, Aifantis I, Roberts KG, Ma J, Song G, Easton J, Mulder HL, Chen X, Newman S, Ma X, Rusch M, Gupta P, Boggs K, Vadodaria B, Dalton J, Liu Y, Valentine ML, Ding L, Lu C, Fulton RS, Fulton L, Tabib Y, Ochoa K, Devidas M, Pei D, Cheng C, Yang J, Evans WE, Relling MV, Pui C-H, Jeha S, Harvey RC, Chen I-ML, Willman CL, Marcucci G, Bloomfield CD, Kohlschmidt J, Mrozek K, Paietta E, Tallman MS, Stock W, Foster MC, Racevskis J, Rowe JM, Luger S, Kornblau SM, Shurtleff SA, Raimondi SC, Mardis ER, Wilson RK, Dick JE, Hunger SP, Loh ML, Downing JR, Mullighan CG. Deregulation of DUX4 and ERG in Acute Lymphoblastic Leukemia. Nat. Genet. 2016 Dec;48(12):1481-1489. Epub 2016 Oct 24. PMID: 27776115. PMCID: 5144107.

Eisfeld A-K, Kohlschmidt J, Mrózek K, Volinia S, Blachly JS, Nicolet D, Oakes C, Kroll K, Orwick S, Carroll AJ, Stone RM, Byrd JC,  de la Chapelle A, Bloomfield CD. The mutational landscape and gene-expression patterns of adult patients with acute myeloid leukemia and monosomy 7 as a sole abnormality. Cancer Res. 2017 Jan 1;77(1):207-218. Epub 2016 Oct 26. PMID: 27784745. PMCID: 5215102.

Gu Z, Li Y, Liu Y, Reshmi S,  Roberts K,  Harvey RC, McCastlain K, Payne-Turner D, Churchman M, Iacobucci I, Shao Y, Chen I-M, Valentine M, Mungall K, Mungall A, Ma Y, Moore R, Marra M, Stonerock E, Gastier-Foster J, Devidas M, Dai Y, Wood B, Borowitz M, Larsen E, Maloney K, Mattano LA, Angiolillo A, Salzer WL, Burke MJ, Rambaldi A, Spinelli O, Radich JP, Minden MD, Moorman AV, Patel B, Fielding AK, Rowe JM, Luger SM, Bhatia R, Aldoss I, Forman SJ, Kohlschmidt J, Mrózek K, Marcucci G, Bloomfield CD, Stock W, Kornblau S, Kantarjian HM, Konopleva M, Paietta E, Willman CL, Loh M, Hunger S, Mullighan C. Genomic analysis identify recurrent MEF2D fusions in Acute Lymphoblastic Leukemia. Nat Commun. Epub 2016 Nov 8;7: article no.13331. PMID: 27824051.  PMCID: 5105166.

Eisfeld A-K, Kohlschmidt J, Schwind S, Nicolet D, Blachly JS, Orwick S, Shah C, Bainazar M, Kroll K, Walker CJ, Carroll AJ, Powell BL, Stone RM, Kolitz JE, Baer MR, de la Chapelle A, Byrd JC, Mrozek K, Bloomfield CD. Mutations in the CCND1 and CCND2 genes are frequent events in adult patients with t(8;21)(q22;122) acute myeloid leukemia. Leukemia. 2017 Jun;31(6):1278-1285. Epub 2016 Nov 15. PMID: 27843138. PMCID: 5462855.

Roberts KG, Gu Z, Payne-Turner D, McCastlain K, Harvey RC, Chen I-M, Pei D, Iacobucci I, Valentine M, Pounds SB, Shi L, Li Y, Zhang J, Cheng C, Rambaldi A, Tosi M, Spinelli O, Radich JP, Minden MD, Rowe JM, Luger S, Litzow MR, Tallman MS, Wiernik PH, Bhatia R, Aldoss I, Kohlschmidt J, Mrózek K, Marcucci G, Bloomfield CD, Stock W, Kornblau SM, Kantarjian HM, Konopleva M, Paietta E, Willman CL, Mullighan CG. High frequency and poor outcome of Philadelphia chromosome-like Acute Lymphoblastic Leukemia in adults. J Clin Oncol. 2017 Feb;35(4):394-401. Epub 2016 Nov 21. PMID: 27870571. PMCID: 5455698.

Eisfeld A-K, Mrozek K, Kohlschmidt J, Nicolet D, Orwick S, Kroll K, Blachly JS, Carroll AJ, Kolitz JE, Powell BL, Wang E, Stone RM, de la Chapelle A, Byrd JC, Bloomfield CD. The mutational oncoprint of recurrent cytogenetic abnormalities in adult patients with de novo acute myeloid leukemia. Leukemia. 2017 Oct;31(10):2211-2218. Epub 2017 Apr 18. PMID: 28321123. PMCID: 5628133.

Walker CJ, Eisfeld A-K, Genutis L, Bainazar M, Kohlschmidt J, Mrózek K, Carroll AJ, Kolitz JE, Powell BL, Wang ES, Stone RM, Bundschuh R, de la Chapelle A, Bloomfield CD. No evidence for microsatellite instability in acute myeloid leukemia. Leukemia. 2017 Jun 31;(6):1474-1476. Epub 2017 Mar 24. PMID: 28336936. PMCID: 5462842.

Papaioannou D, Nicolet D, Volinia S, Mrózek K, Yan P, Bundschuh R, Carroll AJ, Kohlschmidt J, Blum W, Powell BL, Uy GL, Kolitz JE, Wang ES, Eisfeld A-K, Orwick SJ, Lucas DM, Caligiuri MA, Stone RM, Byrd JC, Garzon R, Bloomfield CD. Prognostic and biologic significance of long non-coding RNA profiling in younger adult patients with cytogenetically normal acute myeloid leukemia. Haematologica. 2017 Aug;102(8):1391-1400. Epub 2017 May 4. PMID: 28473620. PMCID: 5541873.

Eisfeld A-K, Kohlschmidt J, Mrozek K, Blachly JS, Walker CJ, Nicolet Dr, Orwick S, Maharry SE, Papaioannou D, Kroll KW, Carroll AJ, Stone RM, de la Chapelle A, Byrd JC, Bloomfield CD. Mutation pattern identifies adult patients with De Novo acute myeloid leukemia aged 60 years or older who respond favorably to standard chemotherapy: An Analysis of Alliance Studies. Leukemia. 2018 Jun;32(6):1338-1348. Epub 2018 Feb 25. PMID: 29563537. PMCID: 5992022.

​​​​​​​Eisfeld A-K, Kohlschmidt J, Mrózek K, Mims A, Walker CJ, Blachly JS, Nicolet D, Orwick S, Maharry SE, Carroll AJ, Powell BL, Kolitz JE, Wang ES, Stone RM, de la Chapelle A, Byrd JC, Bloomfield CD. NF1 Mutations are Recurrent in Adult Acute Myeloid Leukemia and Confer Poor Outcome. Leukemia. Epub 2018 June 5. PMID: 29872168.

Vasu S, Kohlschmidt J, Mrózek K, Eisfeld A-K, Nicolet D, Sterling LJ, Becker H, Metzeler KH, Papaioannou D, Powell BL, Kolitz JE, Moore JO, Baer MR, Roboz GJ, Stone JC, Carroll AJ, Bloomfield CD. Ten-year outcome of patients with acute myeloid leukemia not treated with allogeneic transplantation in first complete remission. Blood Adv. 2018 Jul 10;2(13):1645-1650. PMID: 29991495. PMCID: 6039651.

Ustun C, Morgan E, Moodie EEM, Pullarkat S, Yeung C, Broesby-Olsen S, Ohgami R, Kim Y, Sperr W, Vestergaard H, Chen D, Kluin PM, Dolan M, Mrózek K, Chzuchlewski D, Horny H-P, George TI, Kielsgaard Kristensen T, Yi CA, Møller MB, Marcucci G, Baughn L, Schiefer A-I, Hilberink JR, Shanley R, Kohlschmidt J, Coulombe J, Salhotra A, Soma L, Cho C, Linden M, Akin C, Gotlib J, Hoermann G, Hornick J, Nakamura R, Deeg J, Bloomfied CD, Weisdorf D, Litzow M, Valent P, Huls G, Perales M-A, Borthakur G. Core-Binding Factor Acute Myeloid Leukemia with t(8;21): Risk Factors and The First Validated Scoring System (I-CBFit). Cancer Med. 2018 Sep;7(9):4447-4455. Epub 2018 Aug 16. PMID: 30117318. PMCID: 6144246.

Walker CJ, Oakes CC, Genutis LK, Biacopelli B, Liyanarchchi S, Nicolet D, Eisfeld A-K, Scholz M, Brock P, Kohlschmidt J, Mrózek K, Bill M, Carroll AJ, Kolitz JE, Powell BL, Wang ES, Stone RM, Byrd JC, Schwind S, de la Chapelle A, Bloomfied CD. Genome-wide association study identifies an acute myeloid leukemia susceptibility locus near BICRA. Leukemia. Leukemia. Epub 2018 Oct 5. PMID: 30291333.

Roboz GJ, Mandrekar S, Desai P, Laumann K, Walker AR, Wang ES, Kolitz JE, Powell BL, Attar EC, Stock W, Bloomfield CD, Kohlschmidt J, Mrozek K, Hassane DC, Valbuena JJ, Baltay M, Smith SE, Marcucci G, Stone RM, Larson RA. A randomized trial of 10-day Decitabine with and without Bortezomib in previously untreated older patients with Acute Myeloid Leukemia: CALGB (Alliance) 11002. Blood Adv. 2018 Dec 26;2(24):3608-3617. PMID: 30567725.

Gu Z, Churchman ML, Roberts KG, Moore I, Zhou X, Nakitandw J, Hagiwara K, Pelletier S, Gingras S, Berns H, Payne-Turner D, Hill A, Iacobucci I, Shi L, Pounds S, Cheng C, Pei D, Qu C, Newman S, Devidas M, Dai Y, Reshmi SC, Gastier-Foster J, Raetz EA, Borowitz MJ, Wood BL, Carroll WL, Zweidler-MCKay PA, Rabin KR, Mattano LA, Maloney KW, Rambaldi A, Spinelli O, Radich JP, Minden MD, Rowe JM, Luger S, Litzow MR, Tallman MS, Racevskis J, Zhang Y, Bhatia R, Kohlschmidt J, Mrózek K, Bloomfield CD, Stock W, Kornblau S, Kantarjian HM, Konopleva M, Evans W, Jeha S, Pui C-H, Yan J, Paietta E, Downing J, Relling MV, Loh ML, Hunger SP, Mullighan CG. PAX5-driven Subtypes of B-cell Acute Lymphoblastic Leukemia. Nature Genet. 2019 Feb;51(2):296-307. Epub 2019 Jan 14. PMID: 30643249

Eisfeld A-K, Blachly JS, Mrózek K, Kohlschmidt J, Walker CJ, de la Chapelle A, Bloomfield CD. Implementation of standardized variant-calling nomenclature in the age of next-generation sequencing: where do we stand? Leukemia. 2019 Mar;33(3):809-810. Epub 2019 Jan 24. PMID: 30679803.

Mrózek K, Eisfeld A-K, Kohlschmidt J, Carroll AJ, Walker CJ, Nicolet D, Blachly JS, Bill Marius, Papaioannou D, Wang ES, Uy GL, Kolitz JE, Powell BL, Blum W, Stone RM, Byrd JC, Bloomfield CD.  Complex karyotype in acute myeloid leukemia: typical and atypical subtypes differ molecularly and clinically. Leukemia 2019 Jul;33(7):1620-1634. doi: 10.1038/s41375-019-0390-3. Epub 2019 Feb 8. PMID: 30737482.

Bill M, Papaioannou D, Karunasiri M, Kohlschmidt J, Walker AE, Brannan Z, Mrózek K, LaRocco A, Volinia S, Bloomfield CD, Garzon R, Dorrance AM. Expression and functional relevance of long non-coding RNAs in acute myeloid leukemia stem cells. Leukemia. 2019 Sep;33(9):2169-2182. Epub 2019 Mar 11. PMID: 30858548. 

Papaioannou D, Nicolet D, Ozer HG, Mrózek K, Volina S, Fadda P, Carroll AJ, Kohlschmidt J, Stone RM, Garzon, Bloomfield CD.  Prognostic and Biologic Relevance of Clinically Applicable Long Non-Coding RNA Profiling in Older Patients with Cytogenetically Normal AML. Mol Cancer Ther. 2019 Aug;18(8):1451-1459. Epub 2019 Jun 4. PMID: 31164409. PMCID: 6677601.

Walker CJ, Kohlschmidt J, Eisfeld A-K, Mrózek K, Liyanarachchi S, Song Ch, Nicolet D, Blachly JS, Bill M, Papaioannou D, Oakes CC, Giacopelli B, Genutis LK, Maharri SE, Orwick S, Powell BL, Kolitz JE, Uy GL, Wang ES, Carroll AJ, Stone RM, Byrd JC, de la Chapelle A, Bloomfield CD. Uniparental disomies result in loss of heterozygosity and are associated with outcome in cytogenetically normal acute myeloid leukemia (Alliance). Clin. Cancer Res. 2019 Nov 1;25(21):6524-6531. Epub 2019 Aug 2. PMID: 31375516. PMCID: 6825549.

Bill M, Nicolet D, Kohlschmidt J, Walker CJ, Mrózek K, Eisfeld A-K, Papaioannou D, Rong-Mullins X, Brannan Z, Kolitz JE, Powell BL, Archer KJ, Dorrance AM, Carroll AJ, Stone RM, Byrd JC, Garzon R, Bloomfield CD. Mutations associated with a 17-gene leukemia stem cell score and validation of its prognostic value in AML. Haematologica. 2020 Mar;105(3):721-729. doi: 10.3324/haematol.2019.225003. Epub 2019 Aug 14. PMID: 31413100. 

Bhatnagar B, Eisfeld AK, Kohlschmidt J, Mrózek K, Nicolet D, Papaioannou D, Walker CJ, Orwick S, Blachly JS, Kolitz JE, Powell BL, Carroll AJ, Stone RM, Byrd JC, Bloomfield CD. Clinical and molecular characterization of patients with acute myeloid leukemia and sole trisomies of chromosomes 4, 8, 11, 13 or 21. Leukemia. 2020 Feb;34(2):358-368. doi: 10.1038/s41375-019-0560-3. Epub 2019 Aug 28. PMID: 31462731

Papaioannou D, Petri A, Dovey OM, Terreri S, Wang E, Collins FA, Woodward LA, Walker AE, Nicolet D, Pepe F, Kumchala P, Bill M, Walker CJ, Karunasiri M, Mrózek K, Gardner ML, Camilotto V, Zitzer N, Cooper JL, Cai X, Rong-Mullins X, Kohlschmidt J, Archer KJ, Freitas MA, Zheng Y, Lee RJ, Aifantis I, Vassiliou G, Singh G, Kauppinen S, Bloomfield CD, Dorrance AM, Garzon R. The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia. Nat Commun. 2019 Nov 25;10(1):5351. PubMed PMID: 31767858; PMCID: PMC6877618.

Papaioannou D, Volinia S, Nicolet D, Świerniak M, Petri A, Mrózek K, Carroll AJ, Kohlschmidt J, Eisfeld A-K, Powell BL, Uy GL, Kolitz JE, Wang ES, Kauppinen S, Dorrance A, Stone RM, Byrd JC, Bloomfield CD, Garzon R. Clinical and Functional Significance of Circular RNAs in Cytogenetically Normal Acute Myeloid Leukemia. Blood Adv. 2020 Jan 28;4(2):239-251. PMID: 31945158; PMCID: PMC6988408.

Marcucci G, Geyer S, Laumann K, Zhao W, Bucci D, Uy GL, Blum W, Eisfeld AK, Pardee TS, Wang ES, Stock W, Kolitz JE, Kohlschmidt J, Mrózek K, Bloomfield CD, Stone RM, Larson RA. Combination of dasatinib with chemotherapy in previously untreated core binding factor acute myeloid leukemia: CALGB 10801. Blood Adv. 2020 Feb 25;4(4):696-705. PMID:32092139; PMCID: PMC7042984.

Eisfeld A-K, Kohlschmidt J, Mims A, Nicolet D, Walker CJ, Blachly JS, Carroll AJ, Papaioannou D, Kolitz JE, Powell BE, Stone RM, de la Chapelle A, Byrd JC, Mrózek K, Bloomfield CD. Additional gene mutations may refine the 2017 European LeukemiaNet classification in adult patients with de novo acute myeloid leukemia aged <60 years. Leukemia. 2020 Dec;34(12):3215-3227. doi: 10.1038/s41375-020-0872-3. Epub 2020 May 27. PMID: 32461631; PMCID: PMC7882079.

Mims AS, Kohlschmidt J, Eisfeld AK, Mrόzek K, Blachly JS, Orwick S, Papaioannou D, Nicolet D, Sampath D, Stone RM, Powell BL, Kolitz JE, Byrd JC, Bloomfield CD. Comparison of clinical and molecular characteristics of patients with acute myeloid leukemia and either TP73 or TP53 mutations. Leukemia. 2020 Aug 5:10.1038/s41375-020-1007-6. doi: 10.1038/s41375-020-1007-6. Epub ahead of print. PMID: 32759975; PMCID: PMC7862425.

Ustun C, Morgan EA, Ritz EM, Vestergaard H, Pullarkat S, Kluin PM, Ohgami R, Baughn LB, Kim Y, Ku NK, Czuchlewski D, Boe Møller M, Schiefer AI, Mrózek K, Horny HP, George TI, Kielsgaard Kristensen T, Beck T, Nathan S, Arana Yi C, Yeung C, Pullarkat V, Gotlib J, Akin C, Kohlschmidt J, Salhotra A, Soma L, Chen D, Han SY, Cho C, Sperr W, Broesby-Olsen S, Linden MA, Dolan M, Hoermann G, Hornick JL, Bloomfield C, Nakamura R, Joachim Deeg H, Litzow MR, Borthakur G, Weisdorf D, Huls G, Perales MA, Valent P, Marcucci G. Core-binding factor acute myeloid leukemia with inv(16): Older age and high white blood cell count are risk factors for treatment failure. Int J Lab Hematol. 2021 Feb;43(1):e19-e25. doi: 10.1111/ijlh.13338. Epub 2020 Sep 14. PMID: 32926565.

Bill M, Mrózek K, Kohlschmidt J, Eisfeld AK, Walker CJ, Nicolet D, Papaioannou D, Blachly JS, Orwick S, Carroll AJ, Kolitz JE, Powell BL, Stone RM, de la Chapelle A, Byrd JC, Bloomfield CD. Mutational landscape and clinical outcome of patients with de novo acute myeloid leukemia and rearrangements involving 11q23/KMT2A. Proc Natl Acad Sci U S A. 2020 Oct 20;117(42):26340-26346. doi: 10.1073/pnas.2014732117. Epub 2020 Oct 5. PMID: 33020282; PMCID: PMC7584992.

Bhatnagar B, Kohlschmidt J, Mrózek K, Zhao Q, Fisher JL, Nicolet D, Walker CJ, Mims AS, Oakes C, Giacopelli B, Orwick S, Boateng I, Blachly JS, Maharry SE, Carroll AJ, Powell BL, Kolitz JE, Stone RM, Byrd JC, Paskett ED, de la Chapelle A, Garzon R, Eisfeld AK. Poor Survival and Differential Impact of Genetic Features of Black Patients with Acute Myeloid Leukemia. Cancer Discov. 2021 Mar;11(3):626-637. doi: 10.1158/2159-8290.CD-20-1579. Epub 2020 Dec 4. PMID: 33277314.

Walker CJ, Mrózek K, Ozer HG, Nicolet D, Kohlschmidt J, Papaioannou D, Genutis LK, Bill M, Powell BL, Uy GL, Kolitz JE, Carroll AJ, Stone RM, Garzon R, Byrd JC, Eisfeld AK, de la Chapelle A, Bloomfield CD. Gene expression signature predicts relapse in adult patients with cytogenetically normal acute myeloid leukemia. Blood Adv. 2021 Mar 9;5(5):1474-1482. doi: 10.1182/bloodadvances.2020003727. PMID: 33683341; PMCID: PMC7948288.

Han SY, Mrózek K, Voutsinas J, Wu Q, Morgan EA, Vestergaard H, Ohgami R, Kluin PM, Kristensen TK, Pullarkat S, Møller MB, Schiefer AI, Baughn LB, Kim Y, Czuchlewski D, Hilberink JR, Horny HP, George TI, Dolan M, Ku NK, Arana Yi C, Pullarkat V, Kohlschmidt J, Salhotra A, Soma L, Bloomfield CD, Chen D, Sperr WR, Marcucci G, Cho C, Akin C, Gotlib J, Broesby-Olsen S, Larson M, Linden MA, Deeg HJ, Hoermann G, Perales MA, Hornick JL, Litzow MR, Nakamura R, Weisdorf D, Borthakur G, Huls G, Valent P, Ustun C, Yeung CCS. Secondary cytogenetic abnormalities in core-binding factor AML harboring inv(16) vs t(8;21). Blood Adv. 2021 May 25;5(10):2481-2489. doi: 10.1182/bloodadvances.2020003605. PMID: 34003250; PMCID: PMC8152510.

Mims AS, Kohlschmidt J, Borate U, Blachly JS, Orwick S, Eisfeld AK, Papaioannou D, Nicolet D, Mrόzek K, Stein E, Bhatnagar B, Stone RM, Kolitz JE, Wang ES, Powell BL, Burd A, Levine RL, Druker BJ, Bloomfield CD, Byrd JC. A precision medicine classification for treatment of acute myeloid leukemia in older patients. J Hematol Oncol. 2021 Jun 23;14(1):96. doi: 10.1186/s13045-021-01110-5. PMID: 34162404; PMCID: PMC8220739.

Bill M, Mrózek K, Giacopelli B, Kohlschmidt J, Nicolet D, Papaioannou D, Eisfeld AK, Kolitz JE, Powell BL, Carroll AJ, Stone RM, Garzon R, Byrd JC, Bloomfield CD, Oakes CC. Precision oncology in AML: validation of the prognostic value of the knowledge bank approach and suggestions for improvement. J Hematol Oncol. 2021 Jul 6;14(1):107. doi: 10.1186/s13045-021-01118-x. PMID: 34229733; PMCID: PMC8261916.

Walker AR, Marcucci G, Yin J, Blum W, Stock W, Kohlschmidt J, Mrózek K, Carroll AJ, Eisfeld AK, Wang ES, Jacobson S, Kolitz JE, Thakuri M, Sutamtewagul G, Vij R, Stuart RK, Byrd JC, Bloomfield CD, Stone RM, Larson RA. Phase 3 randomized trial of chemotherapy with or without oblimersen in older AML patients: CALGB 10201 (Alliance). Blood Adv. 2021 Jul 13;5(13):2775-2787. doi: 10.1182/bloodadvances.2021004233. PMID: 34251414; PMCID: PMC8288671

Ferraro F, Miller CA, Christensen KA, Helton NM, O'Laughlin M, Fronick CC, Fulton RS, Kohlschmidt J, Eisfeld AK, Bloomfield CD, Ramakrishnan SM, Day RB, Wartman LD, Uy GL, Welch JS, Christopher MJ, Heath SE, Baty JD, Schuelke MJ, Payton JE, Spencer DH, Rettig MP, Link DC, Walter MJ, Westervelt P, DiPersio JF, Ley TJ. Immunosuppression and outcomes in adult patients with de novo acute myeloid leukemia with normal karyotypes. Proc Natl Acad Sci U S A. 2021 Dec 7;118(49):e2116427118. doi: 10.1073/pnas.2116427118. PMID: 34845035; PMCID: PMC8673586.

Fobare S, Kohlschmidt J, Ozer HG, Mrózek K, Nicolet D, Mims AS, Garzon R, Blachly JS, Orwick S, Carroll AJ, Stone RM, Wang ES, Kolitz JE, Powell BL, Oakes CC, Eisfeld AK, Hertlein E, Byrd JC. Molecular associations, clinical, and prognostic implications of PTPN11 mutations in acute myeloid leukemia (Alliance). Blood Adv. 2022 Mar 8;6(5):1371-1380. doi: 10.1182/bloodadvances.2021006242. PMID: 34847232; PMCID: PMC8905707.

Bill M, Jentzsch M, Bischof L, Kohlschmidt J, Grimm J, Schmalbrock LK, Backhaus D, Brauer D, Goldmann K, Franke GN, Vucinic V, Niederwieser D, Mims AS, Platzbecker U, Eisfeld AK, Schwind S. Impact of IDH1 and IDH2 mutation detection at diagnosis and in remission in patients with AML receiving allogeneic transplantation. Blood Adv. 2022 Apr 5:bloodadvances.2021005789. doi: 10.1182/bloodadvances.2021005789. Epub ahead of print. PMID: 35381077.

Papaioannou D, Ozer HG, Nicolet D, Urs AP, Herold T, Mrózek K, Batcha AMN, Metzeler KH, Yilmaz AS, Volinia S, Bill M, Kohlschmidt J, Pietrzak M, Walker CJ, Carroll AJ, Braess J, Powell BL, Eisfeld AK, Uy GL, Wang ES, Kolitz JE, Stone RM, Hiddemann W, Byrd JC, Bloomfield CD, Garzon R. Clinical and molecular relevance of genetic variants in the non-coding transcriptome of patients with cytogenetically normal acute myeloid leukemia. Haematologica. 2022 May 1;107(5):1034-1044. doi: 10.3324/haematol.2021.266643. PMID: 34261293; PMCID: PMC9052895.

Epstein-Peterson ZD, Derkach A, Geyer S, Mrózek K, Kohlschmidt J, Park JH, Rajeeve S, Stein EM, Zhang Y, Iland H, Campbell LJ, Larson RA, Poiré X, Powell BL, Stock W, Stone RM, Tallman MS. Effect of additional cytogenetic abnormalities on survival in arsenic trioxide-treated acute promyelocytic leukemia. Blood Adv. 2022 Jun 14;6(11):3433-3439. doi: 10.1182/bloodadvances.2021006682. PMID: 35349669; PMCID: PMC9198910.

Larkin K, Nicolet D, Kelly BJ, Mrózek K, LaHaye S, Miller KE, Wijeratne S, Wheeler GL, Kohlschmidt J, Blachly JS, Mims AS, Walker C, Oakes CC, Orwick S, Boateng I, Buss J, Heyrosa A, Desai H, Carroll AJ, Blum W, Powell BL, Kolitz JE, Moore JO, Mayer RJ, Larson RA, Stone RM, Paskett ED, Byrd JC, Mardis E, Eisfeld AK. High early death rates, treatment resistance, and short survival of Black adolescents and young adults with AML. Blood Adv. 2022 Jul 5:bloodadvances.2022007544. doi: 10.1182/bloodadvances.2022007544. Epub ahead of print. PMID: 35788257.